Catalyst for preparation of 6-methyl-1,5-heptadiene

ABSTRACT

A process of producing 6-methyl-1,5-heptadiene by reacting isobutylene with an aliphatic or cycloaliphatic 1,5-diene containing at least 6 carbon atoms in the presence of a catalyst system containing activated rhenium oxide deposited on alumina and a tetra(lower alkyl)metal compound.

United States Patent Fitton et al. Dec. 9, 1975 [54] CATALYST FOR PREPARATION OF 3,67l,462 6/l972 OHara et a]. 260/683 D 6 METHYL 15 HEPTAD[ENE 3,7l5,4l0 2/l973 Ray et al 260/680 R [75] Inventors: Peter Fitton, Pequannock, Ni;

Thomas Whltesides, Madison, Wis. primary w Shine 7 Assignee; H ff L Roche Inc N fl Attorney, Agent, or Firr11Samuel L. Welt; Jon S.

NI]. Saxe; William H. Epstem [22] Filed: Aug. 29, 1974 [2l] Appl. No.: 501,517

ABSTRACT Related U.S. Application Data [62] Division ofSer. No. 409.122, 0m. 24, 1973, Pat. No. A process of roducing 6-methyl-l,5-heptadiene by 3.855.338, reacting isobutylene with an aliphatic or cycloaliphatic 1,5-diene containing at least 6 carbon atoms in the U.S. 4 presence ofa catalyst system cgntaining activated rhe- [5|] Int. Cl. BOIJ 21/04; BOlJ 3l/l2 m oxid d o it d an alumina and a tetraflower of Search 4 alkyl)meta l compound [56] References Cited UNITED STATES PATENTS 5 Claims N0 Drawmgs 3,424,811 1/1969 Mango 260/680 R CATALYST FOR PREPARATION OF fi-METHYL-LS-HEPTADIENE CROSS REFERENCE TO RELATED APPLICATIONS This application is a Divisional application of Ser. No. 409,122 filed Oct. 24, 1973, Fitton et al., now U.S. Pat. No. 3,855,338 issued Dec. 17, I974.

BACKGROUND OF THE INVENTION The compound 6-methyl-l,5-heptadiene is a valuable intermediate for such compounds as -methyLS-hepten-2-one utilized in the production of vitamins and carotenoids. See U.S. Patent application Ser. No. 272,5 1 6, now abandoned, filed July 17, I972, Fitton et al.

In the past, 6-methyl-l,5-heptadiene has been synthesized as disclosed in I-Ienne et al., J.A.C.S., 64 392 (1944) by reacting prenyl chloride and allyl chloride in the presence of magnesium. This process has suffered from the disadvantage that the 6-methyl-l,5-heptadiene is produced in low yields in combination with many side products. Furthermore, this process has proven to be very expensive due to the need of utilizing stoichoimetric amounts of magnesium and the poor efficiency encountered in converting the starting materials to the desired product.

Another method which could be applied to the preparation of 6-methyll ,S-heptadiene is by the disproportionation of olefins utilizing catalysts such as activated rhenium oxide on alumina as disclosed in British Patent No. l,l05,563, I-Iowman et al., British Patent No. 1,174,968, Alkema et al., and U.S. Pat. No. 3,658,927, April 25, I972, Crain et al. The disproportionation of olefins involves the catalytic rearrangement of the oiefins around the double bond contained therein, producing a multiplicity of products. The drawback of this procedure is that the 6-methyll ,S-heptadiene which, if produced at all, is produced in poor yields, in combination with various other olefins. Furthermore, it was found that it was difficult to separate this compound from the various other olefinic compounds contained in this mixture. In view of the fact that it has been difficult and expensive to produce 6-methyl-l,5-heptadine, this compound has not found extensive use as an intermediate. Therefore, it has long been desired to provide a more efficient and cheaper method for the preparation of 6-methyl-l ,S-heptadiene.

SUMMARY OF THE INVENTION In accordance with this invention, it has been found that when an olefinic component containing a compound of the formula:

wherein R and R, are independently selected from the group consisting of hydrogen, lower alkyl or R;,CH=CHCH -CH, or taken together form a lower alkylene or CH,-Cl-I,-CH=A CI-I-CI-I CI-I,; and R is lower alkyl; or mixtures of a compound of formula I is reacted with isobutene, i.e., a compound of the formula:

2 in the presence of a catalyst system containing activated rhenium oxide deposited on alumina and a tetra(- lower alkyl)metal compound of the formula:

Y III wherein R is lower alkyl; and Y is a Group lV-A metal; a mixture is produced having a high content of 6-methyl-l,5-heptadiene and from which 6-methyl-l,5-heptadiene can be easily isolated.

The mixture which is produced by the process of this invention has a high 6-methyl-l,5-heptadiene content. Furthermore, the olefinic products which are contained in this mixture can be easily separated from the desired 6-methyl-l,5-heptadiene by fractional distillation. In addition, many of the side products produced by the reaction of this invention can be recycled to react with the compound of formula II to produce additional 6-methyl-l ,S-heptadiene. The phenomena whereby the disproportionation reaction of a compound of formula I with a compound of formula II to produce an olefinic mixture having a high 6-methyl- 1,5-heptadiene content can be directly attributable to the use of a catalyst system containing an activated rhenium oxide deposited on alumina and a tetra(lower alkyl)metal compound of the formula III. This can be seen by the fact that where a catalyst system containing an oxide of a metal other than rhenium is utilized or the compound of formula III is omitted from the reaction, the disproportionation reaction will not produce a mixture having a high 6-methyl-l,5-heptadiene content. Furthermore, if any of the components of the catalyst system are changed or omitted, isomerization occurs and side products form which cannot be easily separated from the 6-methyl-l,5heptadiene product.

Therefore, the process of this invention provides an economic and efficient method for producing 6-methyll ,5 -heptadiene.

DETAILED DESCRIPTION OF THE INVENTION As used throughout this application, the term lower alkyl" comprehends both straight and branched chain saturated hydrocarbon groups containing from 1 to 7 carbon atoms such as methyl, ethyl, n-propyl, isopropyl, etc. As used throughout this application, the term halogen"-includes all four halogens such as bromine, chlorine, fluorine and iodine, with chlorine, bromine and fluorine being preferred. The term lower alkylene" comprehends polymethylene chains containing from 2 to 7 carbon atoms such as tetramethylene and pentamethylene. In the compound of formula III, any conventional Group IV-A metal can be utilized. Among the preferred metals are included tin, Germanium and lead, with tin being especially preferred.

The catalyst of rhenium oxide, i.e., rhenium heptoxide and alumina contains from about 0.1 to 40 parts by weight of the oxide to parts by weight of the alumina. The rhenium oxide can be activated by conventional means such as by subjecting the rhenium oxide to thermal treatment either in a stream of inert gas such as nitrogen, carbon dioxide or helium, or preferably in a stream of air or oxygen followed by final treatment with an inert gas. Suitably, the catalyst is first treated with air at a temperature in the range of from about 300 to about 900C, preferably from 300 to 600C. for 1 minute to 20 hours and then under similar conditions with an inert gas such as nitrogen.

The activated rhenium oxide-alumina catalyst is prepared by conventional means such as disclosed in British Patent No. l,l05,563, l-lowman et al. Among the preferred methods of preparing this catalyst is by mixing a solution of ammonium perrhenate and alumina and heating this mixture to convert the perrhenate to the heptoxide. In accordance with another embodiment of preparing this catalyst, the alumina can be impregnated with a solution of rhenium heptoxide in an inert organic solvent and the solvent removed by conventional means such as evaporation. Among the preferred solvents are the volatile organic solvents which include lower alkanols preferably lower alkanols containing from l to 4 carbon atoms such as methanol, ethanol, etc., as well as aliphatic ketones and ethers having from l to 4 carbon atoms, dioxane and tetrahydropyran. However, in forming this catalyst, any conventional inert organic solvent can be utilized. This catalyst can be activated by conventional means such as described hereinbefore by heating the catalyst to a temperature of from about 300C. to about 900C, preferably from about 300C. to about 600C.

The process of this invention is carried out by reacting isobutene with the compound of formula I in the presence of the catalyst system containing activated rhenium oxide deposited on alumina and the compound of formula III. In carrying out this reaction, a compound of formula I can be utilized or mixtures of compounds of the formula I can be utilized as the starting material. In carrying out this reaction the isobutene can be utilized as the solvent medium. On the other hand, inert organic solvents can also be present in the reaction medium. If desired, any conventional inert organic solvent can be added to the reaction medium. Among the inert organic solvents which can be utilized are included hydrocarbons such as butane, benezene, toluene, pentane, hexane, etc..

In carrying out this reaction, the temperature and pressure is regulated to maintain the isobutene in the liquid phase. Therefore, any combination of temperatures and pressures which will maintain isobutene in a liquid phase can be utilized in carrying out this reaction. Among the preferred temperatures for carrying out this reaction are temperatures of from -20C. to 85C. Among the preferred pressures for utilization in this reaction are pressures from atmospheric pressure pounds per square inch gauge) to about 300 pounds per square inch gauge. If desired, temperatures above 80C. and pressures above 300 pounds per square inch gauge can be utilized to carry out this reaction. However, since the utilization of such high temperatures and pressures are expensive, it is not generally economically feasible to utilize such high temperatures and pressures.

The olefin of formula I which can be reacted with isobutene to prepare 6-methyll,5-heptadiene can be a single olefin or a mixture of olefins of the formula I. This component can also contain olefins other than the compound of formula I. Since these other olefins are converted to products other than 6-methyl-l,5-heptadiene, the presence of olefins having a formula other than formula I is not very advantageous. This is true since the disproportionation products produced by olefins other than the compound of formula I will provide separation problems. Among the olefins of the compound of formula I which can be utilized in accordance with this invention are included:

1,5-hexadiene;

cyclo-octa-l ,S-diene;

l ,5 ,9-cyclo dodecatriene;

l ,5,9-decatriene;

l ,5-cyclododecadiene;

1,5-decadiene; and

1,5-dodecadiene.

In carrying out the process of this invention, the catalyst system containing the activated rhenium oxide on alumina and the tetra( lower alkyl) metal compound can be present in the reaction medium in catalytic quantities. The catalyst system of this invention can be present in any amount conventional for catalysts in catalytic reactions. Generally, it is preferred that the catalyst system be present in an amount of at least 0.01% by weight based upon the weight of the olefin component. In carrying out this reaction, the catalyst system is generally utilized in an amount of from 0.01% to 50% by weight, based upon the weight of the olefinic component with amounts of from about I% to about 25% being preferred. On the other hand, amounts far in excess of 50% by weight, based upon the weight of the olefinic component, i.e., amounts of 50% or even greater, can be utilized in this reaction. However, in view of the fact that no beneficial results are obtained by utilizing these large amounts of catalyst, and in view of the added expense of utilizing large amounts of catalyst, these large amounts of catalyst are seldom utilized in carrying out the claimed reaction. If desired, the catalyst system can contain other carrier materials in addition to the alumina. Any conventional inert carrier material can be utilized in the catalyst system if desired. Among the preferred carrier materials are included charcoal and carbon. However, in accordance with the preferred embodiment of this invention, the alumina is the only carrier material for the activated rhenium oxide.

In the catalyst system, the tetra(lower alkyl)metal compound is present in an amount of from 0.1% by weight based upon the weight of the catalyst system with the remainder of the catalyst system being activated rhenium oxide on alumina. Generally, it is preferred to utilize the catalyst system containing from about 0. l by weight to about 60% by weight of tetra(- lower alkyl)metal compound with the remainder i.e., from 40% by weight to 99.9% by weight, being activated rhenium oxide on alumina. Therefore, the catalyst system contains at least 40% by weight of the rhenium oxide on alumina. Among the catalyst systems particularly preferred for use in this invention is a catalyst system which contains from about 1% to 20% by weight based upon the weight of the catalyst system, of the tetra( lower alkyl)metal compound with the remainder, i.e. to 99% by weight, being activated rhenium oxide on alumina.

The reaction is carried out by first forming the activated rhenium oxide on alumina catalyst in the aforementioned manner. The catalyst is then placed in a reaction vessel and the olefin feed and the isobutene are then fed to the vessel. The tetra(lower alkyl)metal compound of formula 1]] can be fed into the reaction medium along with the feeds or can be placed in the vessel before the feeds are introduced therein. The disproportionation reaction to produce 6-methyl- 1 ,S-hepried out for periods greaterthan 60 hours. However, since there is no advantage of utilizing such iong reaction times, these reaction times are seldom utilized.

The reaction product contains 6-methyl-1,5heptadiene in combination with other alkadienes. In view of the fact that this reaction produces alkadienes which can be easily separated from 6-methyl-l ,S-heptadiene, the 6methyl-1,5-heptadiene can be separated very easily from the reaction product produced in accordance with this invention. Any conventional method of separation can be utilized to recover pure 6-methyl-l,5- heptadiene from the reaction product produced in accordance with this invention. Among the preferred methods of separation are included fractional distillation. Any conventional method of fractional distillation can be utilized in accordance with this invention. The resulting reaction product of this invention after separation of the 6-methyl-1,5-heptadiene contains other l,5-alkadienes. Therefore, this reaction product can be reutilized as the olefin feed to react with additional isobutene so as to further increase the yield of 6-methyl- 1,5-heptadiene.

The following examples are illustrative of the invention. All temperatures are in degrees centigrade (C.). All are by weight.

EXAMPLE 1 A catalyst was prepared by dissolving Re,O-, (8 g.) in 200 ml. of water and adding this solution to alumina (100 g.). The water was evaporated and the catalyst dried at llC./30 mml-Ig. overnight.

15 g. of this catalyst was loaded into a stainless steel reactor tube and heated to 580C. for 1 hour in air and then for 2 hours under nitrogen. The reactor was cooled to 60C. and a mixture of isobutene (48.3 g.) and 1,5-hexadiene (16.1 g.) was passed through the reactor and collected in a dry-ice trap. Analysis of the reaction product by glc showed the presence of 2.3% by weight of 6-methyl-1,5-heptadiene and 4.2% of 1,5,9- decatriene.

EXAMPLE 2 Percent by weight Percent by weight Sample -rnethyl-l ,S-heptadiene l ,S,9-decatriene EXAMPLE 3 Example 2 was repeated except tetra( n-butyl)tin (3 g.) was added to the liquid feed. The analysis of the first six samples showed the following product distribution:

Percent 6-methyl- Percent 1,5,9- Sample 1 ,5 heptadiene Decatriene l 8.2 5.2 2 l9.l 7.2 3 21.4 7.5 4 21.7 7.9 5 21.7 8.3 6 22.5 9.5

EXAMPLE 4 An 8% by weight Re O -AI Q catalyst was prepared by dissolving 4 grams Re,O-, in 270 ml. of aqueous Nl-LOI-l (s.g. 0.88) and loading this solution onto 46 grams of A1 0 This catalyst (20 g.) was loaded into a stainless steel reactor tube and activated by heating air at 580C. for 1 hour and in nitrogen at 580C. for 1 hour.

A solution of 1,5-hexadiene (82 g.) and tetra(nbutyl)tin (3 g.) in isobutene (427 g.) was then passed through the reactor tube at 40C. and 120 psig over a period of minutes (Weight Hour Space Velocity 16). The product stream was collected in a vessel cooled to 78. The collected product was analyzed by glc and was found to contain (after the exclusion of isobutene) 6-methyl-1,5-heptadiene 7.72% and 1,5,9- decatriene 11.3%.

When this reaction was repeated exactly as above except that the tetrabutyl tin ws omitted, the product was found to contain on glc analysis (isobutene was excluded) 6-methyl-l ,S-heptadiene 0.37% and 1,5,9- decatn'ene 0.86%.

EXAMPLE 5 An 8% Re,O-,-Al,0, catalyst was prepared and activated as in Example 4.

A solution of l,5-cyclooctadiene (54 g.) and tetra(nbutyl)tin (3 g.) in isobutene (446 g.) was passed through the reactor tube contaning this catalyst (20 g.) at 40 and 120 psig over a period of minutes (WHSV 15). The product stream was collected at -78. A sample of the homogeneous product was analyzed by glc and was found to contain (after excluding isobutene); l,5-hexadiene 1.63%, 6-methyl-1,5-heptadiene 4.83%, 1,5,9-decatriene 1.69%, 2,7-dimethyl- 2,6-octadiene 5.2%, l,5,9,13-tetradecatetraene 7.9% and 1,5-cyclooctadiene 63.8%. Other unidentified higher boiling products (8.8%) which were apparently higher disproportionation products were also formed. Weight Hour Space Velocity EXAMPLE 6 An 8% Re,O-,-Al,0=, catalyst was prepared and activated as in Example 4.

A solution of 1,5,9-cyclododecatriene (mixed isomers) (54 g.) and tetra(n-butyl)tin (3 g.) in isobutene (452 g.) was passed through the reaction tube containing the catalyst (20 g.) at 40 and psig at a Weight Hour Space Velocity 15. After 15 minutes the liquid product stream was sampled. Analysis of this sample by glc showed the following product distribution (after exclusion of isobutene); 1,5-hexadiene 2.4%, 6-methy1- 1,5-heptadiene 7.2%, 1,5,9-decatriene 1.61%, 2,7- dimethyl-2 ,6-octadiene 7 .2%, 1 ,5 ,9 ,1 3-tetradecatetraene 3.6% and 1,5,9-cyclododecatriene 74.2%.

EXAMPLE 7 A solution of tetra(n-butyl)lead (1.3 g.) and nnonane 1.3 g.) (as an internal glc standard) in 1,5-hexadiene (24.6 g.) was added over a period of one hour to a slurry consisting of isobutene'(l20.5 g.) and 8% Re-,O-,-Al,0;. catalyst (5.9 g.) (prepared and activated as in Example 4) contained in a mechanically stirred stainless steel autoclave (capacity 300 ml.) at 40C. and 125 p.s.i.g. pressure maintained by the inert gas argon. After a further 3 hours under these conditions, coolings to room temperature and filterings afforded a homogeneous product which on analysis by glc was found to contain isobutene 72.58% by weight, nnonane 1.86% by weight, 1,5-hexadiene 10.16% by weight, 6-methyl-l,5-heptadiene 2.56% by weight and l,5,9,13-tetradecatetraene 6.98% by weight. Other unidentified products (5.86% by weight) were also formed.

EXAMPLE 8 ln a stainless steel reactor tube was placed 25 g. of an 8% Re,O-,-Al,0, catalyst. The catalyst was activated by heating at 580C. for one hour in a stream of air and for 2 hours in a stream of nitrogen, and then cooled to 40C.

A mixture of isobutene (500 g.), 1,5-hexadiene (82 g.) and tetra(n-butyl)tin (3 g.) was then passed through 8 the reaction tube at p.s.i.g. over a time of 7 hours. The reaction product was flask distilled to remove the excess isobutene and the residue was distilled to give a fraction bp. 1 18-121 18.1 g.) which was shown by ir and nmi to be identical to an authentic sample of 6- methyl-l ,S-heptadiene.

We claim:

1. A catalyst system comprising at least 0.1% by weight, based on the weight of the catalyst system of a tetra(lower allcyl)tin and at least 40% by weight, based upon the weight of the catalyst system of rhenium oxide on alumina.

2. The catalyst system of claim 1 wherein said catalyst system contains 0.1 to 40 parts by weight of rhenium oxide per parts by weight on alumina.

3. The catalyst of claim 2 wherein said catalyst system contains from about 0.1% to about 60% by weight of tetra(lower alkyl)tin and from 40% to about 99.9% by weight, based upon the weight of the catalyst system of rhenium oxide on alumina.

4. The system of claim 1 wherein the tetra(lower a1- kyl)tin is tetra( n-butyl)tin.

5. The system of claim 4 wherein the catalyst system contains from 1% to 20% by weight based upon the weight of the catalyst system of tetra(lower alkyl)tin and from 80% to 99% by weight based upon the weight of the catalyst system of rhenium oxide on alumina.

l I I B 

1. A CATALYST SYSTEM COMPRISING AT LEAST 0.1% BY WEIGHT, BASED ON THE WEIGHT OF THE CATALYST SYSTEM OF A TETRA(LOWER ALKYL)TIN AND AT LEAST 40% BY WEIGHT, BASED UPON THE WEIGHT OF THE CATALYST STSTEM OF RHENIUUM OXIDE ON ALUMINA.
 2. The catalyst system of claim 1 wherein said catalyst system contains 0.1 to 40 parts by weight of rhenium oxide per 100 parts by weight on alumina.
 3. The catalyst of claim 2 wherein said catalyst system contains from about 0.l% to about 60% by weight of tetra(lower alKyl)tin and from 40% to about 99.9% by weight, based upon the weight of the catalyst system of rhenium oxide on alumina.
 4. The system of claim 1 wherein the tetra(lower alkyl)tin is tetra(n-butyl)tin.
 5. The system of claim 4 wherein the catalyst system contains from 1% to 20% by weight based upon the weight of the catalyst system of tetra(lower alkyl)tin and from 80% to 99% by weight based upon the weight of the catalyst system of rhenium oxide on alumina. 